By OpenMed, Open-Source Agentic AI for Healthcare & Life Sciences TL;DR: We built an end-to-end protein AI pipeline covering structure prediction, sequence design, and codon optimization. After comparing multiple transformer architectures for codon-level language modeling, CodonRoBERTa-large-v2 emerged as the clear winner with a perplexity of 4.10 and a Spearman CAI correlation of 0.40, significantly outperforming ModernBERT. We then scaled to 25 species, trained 4 production models in 55 GPU-hours, and built a species-conditioned system that no other open-source project offers. […]

A few weeks ago, we wrote about one-shotting full web apps with gr.HTML: building rich, interactive frontends entirely inside Gradio using custom HTML, CSS, and JavaScript. That unlocked a lot. But what if that’s not enough? What if you want to build with your own frontend framework entirely like React, Svelte, or even plain HTML/JS, while still benefiting from Gradio’s queuing system, API infrastructure, MCP support, and ZeroGPU on Spaces? That’s exactly the problem gradio.Server solves. And it changes what’s […]

Today, we’re announcing that Safetensors has joined the PyTorch Foundation as a foundation-hosted project under the Linux Foundation, alongside DeepSpeed, Helion, Ray, vLLM, and PyTorch itself. How we got here Safetensors started as a Hugging Face project born out of a concrete need: a way to store and share model weights that couldn’t execute arbitrary code. The pickle-based formats that dominated the ecosystem at the time meant that there was a very real risk you’d be running malicious code. While […]

Most AI agents re‑read transcripts instead of learning principles, so they repeat mistakes and don’t transfer lessons to new situations. ALTK‑Evolve turns raw agent trajectories into reusable guidelines. In benchmarks, the approach boosted reliability, especially on hard (Δ 14.2% on AppWorld), multi‑step tasks, without bloating context. The “eternal intern” problem Imagine a brilliant line cook who has memorized every cookbook but forgets your kitchen every morning. They don’t remember your oven runs hot, or that regulars like extra salt; they’ll […]

Sentence Transformers is a Python library for using and training embedding and reranker models for applications like retrieval augmented generation, semantic search, and more. With the v5.4 update, you can now encode and compare texts, images, audio, and videos using the same familiar API. In this blogpost, I’ll show you how to use these new multimodal capabilities for both embedding and reranking. Multimodal embedding models map inputs from different modalities into a shared embedding space, while multimodal reranker models score […]

Waypoint-1.5 Weights on the Hub Try it What is Waypoint-1.5? Waypoint-1.5 is Overworld’s next real-time video world model, built to bring interactive generative worlds to the hardware people actually own. The first release of Waypoint showed that real-time generative worlds were possible. It proved that interactive world models could be more than passive video demos, and that locally runnable systems could begin to close the gap between generating a world and actually stepping into one. Waypoint-1.5 builds directly on that […]