MoLeR: Creating a path to more efficient drug design
Drug discovery has come a long way from its roots in serendipity. It is now an increasingly rational process, in which one important phase, called lead optimization, is the stepwise search for promising drug candidate compounds in the lab. In this phase, expert medicinal chemists work to improve “hit” molecules—compounds that demonstrate some promising properties, as well as some undesirable ones, in early screening. In subsequent testing, chemists try to adapt the structure of hit molecules to improve their biological […]
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